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qooxdoo is an advanced open-source JavaScript-based GUI framework. It helps you to implement AJAX-enhanced web 2.0 applications - easier than ever before.

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Ranked:

#7 in Ajax Frameworks, #7 in JavaScript Library, #8 in JavaScript Frameworks, #8 in Toolkit, #12 in RIA, #21 in Frameworks, #30 in Ajax, #36 in Web Frameworks, #53 in Gui, #106 in UI